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Journeying Beyond: The Digital Twin Frontier in Health and Pharma Evolution
Journeying Beyond: The Digital Twin Frontier in Health and Pharma Evolution

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In the era of Industry 4.0, Digital Twins, powered by the convergence of groundbreaking technologies, are making a significant impact across various fields. Healthcare experiments are producing essential results, shaping their application across different dimensions in the healthcare sector.

Digital Twin for Patient Management:

Digital Twin can be used in preventive healthcare by incorporating a virtual replica of an individual. This is called Human Digital Twin incorporating factors such as genetic heritage, lifestyle, and environmental elements. It ranges from representing the entire human body to specific organs. The data is collected from wearable sensors, lifestyle information and clinical institutions. Human Digital Twin also allows creating of numerous digital replicas of patients which enables the testing of different drugs to identify the most effective treatment for each patient.

Examples: Initiatives like the "SIMULIA Living Heart" project use digital twin technology to observe the body's interaction with drugs through computer simulations, allowing physicians to explore the complex structure of the heart and detect events related to conditions such as ischemic heart disease (IHD).

Digital Twin in Pharma Industry:

The pharmaceutical industry is going through a paradigm shift with the advent of Industry 4.0, taking part in the digitization movement referred to as Pharma 4.0. In the pharma product development cycle, Digital Twin can contribute to smart manufacturing. The digital twins can help in selecting the most optimized and effective production path, real time process control as well as biomanufacturing reducing physical experiments time and cost, increasing productivity, and improving product quality.

Complex and dynamic relationships between molecules and biological networks for drug discovery presents quite time intensive process with low chances of success. Top-down approaches can be explored via integration of Digital twin to drug discovery processes, biomarker identification and clinical trial optimization.

Examples: Modelling of genomic and cellular bioprocesses has been actively supported by funding organizations such as National Science Foundation (NSF); Défense Advanced Research Projects Agency (DARPA) in the US and has led to high-profile projects like Bio spice.

Digital Twin in Public Health Management:

Digital twin can prove to be very helpful in terms of analyzing public health at mass level. It can be helpful in promoting the population well being and in terms of sudden outbreaks, managing viral diseases such as COVID 19 etc.

Examples: 3D animation of radiology department of Mater Private Hospital, made by Siemens Healthineers to improve hospital processes during increased patient demand, increased wait times.

Digital Twin in Physicians and Surgeons Training and Practice:

DT technology may be used to simulate invasive clinical procedures, to predict the outcome before the therapy is selected, increase intervention success, and reduce patient risks.

Examples: Dassault Systems created digital twin of Computer modelling that showed the position of the designed bracelet with 3D modelling and flow simulation. It helped in treating an 18-year-old patient with an enlarged right atrium in the Department of Cardiac Surgery of Boston Children’s Hospital. 


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Madhumay
Deputy Manager - Research

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